Apart from modeling for photobooks, Horikita appeared in magazines and television advertisements.
She is best remembered for her television commercials for Fujifilm(where she appeared alongside Japanese idol Tomoya Nagase) and Lotte.
She debuted in 2003, and has starred in 'numerous Japanese television dramas, television and magazine advertisements, and movies.
Horikita's popular roles include the introverted high school student Nobuko Kotani in Nobuta wo Produce, the cross-dressing sports fan Mizuki Ashiya in Hanazakari no Kimitachi e, and a town doctor during Japan's post-war era Umeko Shimomura in Umechan Sensei.
In the same year that Hana Kimi was filmed, Horikita also starred in the Taiga drama Atsuhime with Aoi Miyazaki.
In the same year, she played the lead character who has multiple personality disorder in the suspense movie Tokyo Shōnen and reprised her role as a student apprentice in Always: Zoku Sanchome no Yuhi, the sequel to her breakthrough movie.
In 2008, Nihon Monitor recognized Horikita as one of Japan's top endorsers during its annual Most Popular Personality in TV CMs.
Months later, she was given the lead role for Teppan Shoujo Akane and the role of a bully who is behind a class rebellion in Seito Shokun!
where she co-starred with her agency senior Rina Uchiyama.
She worked on TBS's "Tokujo Kabachi"along side Sakurai Sho and appeared several times on "Himitsu no Arashi chan".
She has been romanticly linked to Yamashita Tomohisa, Sakurai Sho and Osamu Mukai but this is only wishful thinking from the fans, since she has never had any real gossip or news about a relationship with any of her friends from her line of work.
On March 2, 2017, She officially announced her retirement from the entertainment industry to look after her family as a mother at home.